Below is information about the research studies our lab is conducting. Please read the brief description of the study and if you are interested in volunteering please contact us at (313) 577-5404 or tnp2lab_volunteer@lists.wayne.edu.

effects of thc on retention of memory for fear extinction learning in ptsd: r61 study

*We are actively recruiting for this study.

This study will examine the effects of a drug on behavior, fear conditioning, and emotions in trauma-exposed volunteers and participants with symptoms of posttraumatic stress disorder. 

You will undergo a 3 hour psychiatric and medical screening visit before being accepted in the study. If you are selected to participate, you will participate in 4 more sessions. The first 3 sessions will be scheduled on consecutive days. Approximately, 1 week later you will complete the final session. During these sessions you will be performing some computer tasks in an MRI scanner. An MRI scanner is a large magnet that lets us take pictures of your brain. There is no radioactive dye or x-rays used.  During some of these tasks you will experience aversive stimuli (e.g. virtual snake), which will be unpleasant. We will measure physiological responding through electrodes placed on your skin during each visit. During the third visit you may be asked to ingest a capsule containing either Marinol (THC, cannabinoid, a marijuana-like drug approved by the Food & Drug Administration) or Placebo (sugar). If you do receive a capsule you will not be allowed to drive yourself home, so should arrange for transportation or a taxi can be called for you and will be paid for by the study. During these visits, you might get your blood drawn as well. An IV may be placed in your arm during visits 3, 4, and 5. At the end of the finial visit, we will hold a debriefing session in which we will explain the study procedures to you in more detail. If you complete all study procedures, you will be paid up to $110-$260 for your participation.

Martial arts therapy for pediatric cancer pain and emotional distress

*We are actively recruiting for this study.

This study will examine whether a martial arts therapy, “Kids Kicking Cancer”, can reduce pediatric cancer pain and emotional distress, and promote healthy brain development in children. 

Childhood cancer patients and survivors, ages 5-12, may be eligible to participate in this study. 

The study involves two visits at Wayne State University, lasting about 3.5 hours each day. Caregiver and child will attend both sessions. During sessions, the child will complete questionnaires and interviews about their feelings and emotions, practice laying still with a mock (practice) MRI scanner, and complete a <1 hr MRI brain scan, during which the child will watch movies and play games. Between the two visits, children will participate in four 1-hr Kids Kicking Cancer classes each week (free of charge), at one of 8 Metro Detroit locations. Participating families will expect to receive $200 compensation and a picture of their child’s brain. For more information, please contact Farrah at 586-232-5462. 

MRI is a large magnet that allows us to take pictures of the brain. It is completely non-invasive, with no radioactive dye or x-ray. For more information about what it’s like for a child to have an MRI brain scan, please see the link below:

http://www.tnp2lab.org/think-study-video/

effects of faah genotype on fear-related brain activation

*We are actively recruiting for this study.

This study will examine the effects of genetics and emotions in healthy volunteers.

You will undergo a 1 hour psychiatric and medical screening visit before being accepted in the study.  If you are selected to participate, you will participate in 2 more sessions (1 hour each).  Sessions need be scheduled on consecutive days. During these sessions you will be performing some tasks in an MRI scanner.  An MRI scanner is a large magnet that lets us take pictures of your brain.  There is no radioactive dye or x-rays used.  During some of these tasks you will experience aversive stimuli (e.g. loud noise, snake), which will be unpleasant, but not painful. We will measure physiological responding through electrodes placed on your skin during each visit. If you complete all study procedures, you will be paid up to $50 for your participation.

Cannabinoid Control of Fear Extinction Neural Circuits in Post-Traumatic Stress Disorder

*We are actively recruiting for this study.

This study will examine the effects of a drug on behavior, fear conditioning, and emotions in healthy volunteers and participants with symptoms of posttraumatic stress disorder. 

You will undergo a 2 hour psychiatric and medical screening visit before being accepted in the study.  If you are selected to participate, you will participate in 3 more sessions (1 hour, 5 hours, and 2 hours).  Sessions need be scheduled on consecutive days. During these sessions you will be performing some computer tasks in an MRI scanner.  An MRI scanner is a large magnet that lets us take pictures of your brain.  There is no radioactive dye or x-rays used.  During some of these tasks you will experience aversive stimuli (e.g. loud noise), which will be unpleasant, but not painful. We will measure physiological responding through electrodes placed on your skin during each visit.  At the beginning of the 5 hour session, you will ingest a capsule containing either Marinol (THC, cannabinoid, a marijuana-like drug approved by the Food & Drug Administration) or Placebo (sugar).  During this session you will complete some questionnaires asking about your current mood and feelings.  In addition, during this visit, you will not be allowed to drive yourself home, so should arrange for transportation or a taxi can be called for you.  At the end of the final session we will conduct a debriefing session.  If you complete all study procedures, you will be paid up to $110 for your participation. 

Childhood adversity and brain and behavioral development in children

*We are actively recruiting for this study

This study will examine brain systems that underlie learning and memory in 6-9 year old children who have or have not experienced adversity (violence, abuse, medical trauma) 

The experiment happens over the course of one weekend (Saturday and Sunday), for about 3.5 each day. Caregiver and child will attend both sessions. On Saturday, the child will complete several games that test learning and memory on the computer and on an advanced virtual reality platform - that makes it more fun for kids. We will also interview caregiver and child about life experiences, emotions, and family life. The child will also watch a video of what it’s like for a child to have an MRI brain scan. The MRI will happen on the second day. On Sunday’s session, we will practice laying still in the scanner with a mock or practice MRI machine. The child will be laying down in the real MRI machine for about an hour. During the scan, they will play some games and watch a movie. There will also be times when they can lay awake quietly and relax. For participating, you will receive a picture of your child’s brain and $110 for each visit ($220 for the entire weekend). Additionally, you will receive a $30 giftcard for completing a sleep take-home packet on Saturday evening and Sunday morning. For more information, please contact Farrah at 586-23-CLIMB (25462). 

MRI is a large magnet that allows us to take pictures of the brain. It is completely non-invasive, with no radioactive dye or x-ray. For more information about what it’s like for a child to have an MRI brain scan, please see the link below:

http://www.tnp2lab.org/think-study-video/

Neurophysiological and genetic correlates of posttraumatic stress disorder risk and resilience in michigan police officers

*WE are actively recruiting for this study.

This study will examine brain activation during emotional processing and how it may be impacted by traumatic experience because you are currently an "in-service" student police officer in a Michigan police academy.

The purpose of this study is to better understand the risk factors of posttraumatic stress disorder (PTSD).  If you qualify for the study and decide to participate, you will be asked to attend three study visits over one year that last approximately 2-3 hours per visit. The first visit will occur while you are still in your police academy training; the second visit will occur approximately six months after you graduate from the academy and begin your first job as a police officer and the third approximately 12 months after you begin working as a police officer.  During the study visits, you will perform some computer tasks while wearing an electroencephalogram (EEG) cap, which is an instrument that records brain activity. We will also ask you questions about your trauma and medical history and questions about how you feel.  You will also be asked to allow genetic testing on a biological specimen (a cheek swab) that will be collected and stored as part of the study at each study visit and used to prepare DNA used to study potential causes and effects of PTSD or anxiety disorders.  If you complete all study procedures, you will be paid up to $300 for your participation.